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Glutaminase C-IN-1
CAS No. 311795-38-7
Glutaminase C-IN-1( GLS-IN-968 | Glutaminase inhibitor-968 )
Catalog No. M17473 CAS No. 311795-38-7
Glutaminase C-IN-1 is a Glutaminase C allosteric inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 50 | In Stock |
|
| 10MG | 80 | In Stock |
|
| 25MG | 149 | In Stock |
|
| 50MG | 258 | In Stock |
|
| 100MG | 383 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGlutaminase C-IN-1
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NoteResearch use only, not for human use.
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Brief DescriptionGlutaminase C-IN-1 is a Glutaminase C allosteric inhibitor.
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DescriptionGLS-IN-968 is an allosteric inhibitor of glutaminase (GLS). It acts by blocking Rho-GTPase-dependent transformation of fibroblasts and suppressing breast cancer cell growth and invasive activity in vitro.
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In VitroCell Viability Assay Cell Line:MDA-MB231 cells, SKBR3 cells, and NIH 3T3 cells Concentration:10 μM Incubation Time:5 h Result:Inhibited cell growth.
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In VivoAnimal Model:SCID mice with P493 B lymphoma cellsDosage:200 μg/mouse Administration:Intraperitoneal injection, daily for 12 days Result:Caused a ~50% reduction in the size of the tumors.
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SynonymsGLS-IN-968 | Glutaminase inhibitor-968
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PathwayOthers
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TargetOther Targets
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RecptorGlutaminase C
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number311795-38-7
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Formula Weight475.43
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Molecular FormulaC27H27BrN2O
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Purity>98% (HPLC)
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SolubilityDMSO : 25 mg/mL. 52.59 mM;
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SMILESCC1(CC2=C(C(Nc3c2c2ccccc2cc3)c2cc(c(cc2)N(C)C)Br)C(=O)C1)C
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Chemical Name5-[3-Bromo-4-(dimethylamino)phenyl]-2,3,5,6-tetrahydro-2,2-dimethylbenzo[a]phenanthridin-4(1H)-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Stalnecker CA, et al. Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells. Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):394-9.
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